Perhaps the most important historical advance in the treatment of hyperuricemia was the development of xanthine oxidase inhibitors, which are effective in reducing plasma and urinary urate levels and have been shown to reverse the development of tophaceous deposits. In the modern era, nonsteroidal anti-inflammatory drugs are usually the drugs of choice for treating acute gout. Uricosuric agents were first used at the end of the 19th century. Although there is evidence that colchicine, an alkaloid derived from the autumn crocus (Colchicum autumnale), was used as a powerful purgative in ancient Greece more than 2000 years ago, its first use as a selective and specific treatment for gout is attributed to the Byzantine Christian physician Alexander of Tralles in the sixth century AD. Because it is clearly associated with a lifestyle that, at least in the past, could only be afforded by the affluent, gout has been referred to as the 'disease of kings'. Throughout history, gout has been associated with rich foods and excessive alcohol consumption. The term is derived from the Latin word gutta (or 'drop'), and referred to the prevailing medieval belief that an excess of one of the four 'humors'-which in equilibrium were thought to maintain health-would, under certain circumstances, 'drop' or flow into a joint, causing pain and inflammation. Larson at Sole Foot and Ankle Specialists in Glendale, Arizona.First identified by the Egyptians in 2640 BC, podagra (acute gout occurring in the first metatarsophalangeal joint) was later recognized by Hippocrates in the fifth century BC, who referred to it as 'the unwalkable disease'. Uric acid comes from the breakdown of purine we ingest from the food we eat, and is usually processed by our kidneys and then eliminated with our urine. If you notice any changes your foot health, please consider making an appointment with Dr. Gout is an inflammation caused by the accumulation of needle-like crystals of uric acid deposited in joints, tendons or their surrounding tissues. It is important to take treatment and prevention seriously. Some lifestyle changes that can help decrease gout flare-ups include limiting alcohol and red meats, exercising on a regular basis, maintaining proper weight, and drinking plenty of water.Īn attack of gout can strike more then once. Managing additional gouty attacks will include medications that block the production of uric acid or increase excretion. Treatment for an acute gouty attack typically includes anti-inflammatory medication (such as ibuprofen), Colchicine, and/or corticosteroids to help relieve the swelling and pain. Consuming a large amount of meat and seafood (high purines). The big toe joint is the most common site of attack.With chronic gout, pain may be more achy and sore.Inflammation, severe pain, redness or warmth at the affected site.Below are common symptoms and risk factors for gout. It commonly appears in men around the 4 th and 5 th decade of life, but later in women. called podagra and Hippocrates called “the unwalkable disease.” This disease has been around for a very long time.Īs mentioned above gout results from the deposits of uric acid crystals in tissues within the body. What we call gout today, Egyptian’s in 2640 B.C. Our body uses purines to build DNA, so they are necessary for life however, a buildup of these purines will cause uric acid levels to rise and deposit uric acid crystals in joints, most commonly the big toe joint. Gout is a historic disease that was commonly associated among the wealthy due to the availability of rich-type foods and alcohol filled with purines. Have you ever had a red, hot, swollen big toe that came on over night and is excruciating to touch? Initially you may think infection but you don’t recall stubbing it or having any kind of cut to let the infection in.
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